Leishmania species is a topic covered in the Johns Hopkins HIV Guide.

To view the entire topic, please or purchase a subscription.

Johns Hopkins Guides provide diagnosis, management, and treatment guidance for infectious diseases, diabetes, and psychiatric conditions. Explore these free sample topics:

Johns Hopkins Guides

~~ The first section of this topic is shown below ~~

MICROBIOLOGY

  • Protozoan parasite, HIV increases risk of visceral (hepatosplenic and bone marrow) disease but not cutaneous or mucocutaneous disease.
  • Transmitted by sand fly vectors. Also may be acquired through shared needles among IDUs, primarily in endemic urban settings.
    • Zoonosis: reservoirs
      • Canine: L. infantum, L. chagasi
      • Anthroponotic: L. donovani
  • Forms:
    • Visceral leishmaniasis: L. donovani (Asia), L. infantum (southern Europe, Mediterranean), L. chagasi (Brazil).
    • Cutaneous leishmaniasis: L. major and L. tropica (Old World), L. mexicana, L. amazonensis, L. peruviana, L. guyanensis (New World), L. (viania) braziliensis (cutaneous and mucocutaneous)
  • Amastigote forms seen within macrophages; flagellated promastigote forms seen in cultures, transmitted from insect vector.
  • Leishmania and HIV co-localize in similar cells (macrophages, dendritic cells) resulting in additive immune dysfunction, especially in macrophages leading to increased immune activation.

~~ To view the remaining sections of this topic, please
or purchase a subscription ~~

Last updated: June 2, 2015