Cryptococcal Meningitis is a topic covered in the Johns Hopkins HIV Guide.

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PATHOGENS

  • Cryptococcus neoformans var. neoformans (serotypes A and D).
  • Cryptococcus neoformans var. gattii (serotypes B and C, rare in HIV).
  • Cryptococcus neoformans var. grubii (has been used to designate serotype A).
  • Yeast-like round fungus, 5-10 µm with polysaccharide capsule
  • Epidemiology: found worldwide in soil; major OI in sub-saharan Africa,Thailand, India. In US pre-HAART era 5-8% of HIV+ pts developed cryptococcosis. Dramatically reduced incidence in HAART era.

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Last updated: March 13, 2012