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- Dimorphic fungus existing as a mycelial form in nature and as endosporulating spherule in tissue. Lives in soil.
- Infection acquired through inhalation of arthroconidia, which are then converted to spherules within 48 hrs.
- Endemic in central CA, southern AZ, southern NM, and west TX, northern Mexico, and parts of Central and South America.
- Coccidioides immitis
- Coccidioides posadasii