Johns Hopkins HIV GuideDiagnosisMalignancies

Castleman disease

Mark Levis, M.D., Ph.D., Nina Wagner, M.D.
Castleman disease is a topic covered in the Johns Hopkins HIV Guide.

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PATHOGENS

  • HIV-associated Castleman's disease (CD) always associated with HHV-8, aka Kaposi sarcoma-associated herpesvirus (KSHV). HHV-8 present in 40% of non-HIV cases.
  • CD is likely the result of active lytic infection with HHV-8 as opposed to latent infection with HHV-8-associated primary effusion lymphoma.

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Last updated: February 2, 2011