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Algorithm for Sequencing Glucose-Lowering Therapies in Type 2 Diabetes

Algorithm for Sequencing Glucose-Lowering Therapies in Type 2 Diabetes is a topic covered in the Johns Hopkins Diabetes Guide.

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INTRODUCTION

  • About 29.1 million people or 9.3% of the US population had diabetes in 2012. Of these, approximately 8.1 million or 27.8% had undiagnosed diabetes.
  • Glycemic management in type 2 diabetes is complex and evolving, with many new therapies for type 2 diabetes having been introduced over the past few years.
  • More recent guidelines emphasize a patient-centered approach and also take into consideration patient factors when choosing therapies and appropriate glycemic goals (i.e. patient involvement and expected efforts, comorbidities especially established vascular complications, disease duration, life expectancy).
  • Other factors to consider when choosing therapies for type 2 diabetes might include: efficacy, cost, available resources and support system, fasting versus postprandial hyperglycemia, risk of hypoglycemia, weight changes, drug side effects, route of administration, drug’s mechanism of action.

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Last updated: December 19, 2014