Neurodegenerative Diseases and Mild Cognitive Impairment
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- Neurodegenerative diseases include conditions which primarily affect the neurons in the human brain and are more common in persons with diabetes.
- Examples of neurodegenerative diseases are: Alzheimer’s disease (AD), Parkinson’s disease (PD) and PD-related disorders, Fronto-temporal Dementia, Prion disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, Spinocerebellar ataxia, and Spinal muscular atrophy.
- Dementia is defined as a global cognitive and functional decline in the presence of a clear sensorium.
- AD is thought to account for at least 50% of dementia cases and will be the focus of the present discussion.
- There has been a growing recognition of individuals with cognitive impairment at a severity level insufficient for a diagnosis of dementia. Two terms have been used to describe these individuals: Cognitive impairment, no dementia (CIND) and mild cognitive impairment (MCI).