Amyotrophy is a topic covered in the Johns Hopkins Diabetes Guide.

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  • An underdiagnosed condition referred to by different names including "diabetic proximal amyotrophy", "diabetic lumbosacral plexopathy", "diabetic lumbosacral radiculoplexopathy", "ischemic mononeuropathy multiplex", "femoral-sciatic neuropathy", "femoral neuropathy", "diabetic cachexia" and "Bruns-Garland syndrome".
  • Classically, a monophasic illness characterized by acute or subacute, progressive, asymmetrical lower limb muscle weakness (i.e. back, buttocks or thigh) a few weeks after severe pain onset with variable degrees of recovery.
  • Patients typically also have diabetic peripheral neuropathy (DPN).
  • Differentiated from diabetic polyneuropathy by the spatial pattern of involvement, time course, and prominent motor involvement.
  • Important to diagnose diabetic amyotrophy (DA) because treatment differs from DPN.

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Last updated: November 9, 2011