Johns Hopkins Antibiotic (ABX) GuidePathogensFungi

Paracoccidioides brasiliensis

Valeria Fabre, M.D.
Paracoccidioides brasiliensis is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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MICROBIOLOGY

  • Dimorphic fungus.
    • At 37°C appears as an oval to round yeast cell variable in size, 4-40 μm.
    • The classic "ship’s wheel" structure [ Fig 1] represents a mother cell surrounded by narrow base budding daughter cells.
  • Four different phylogenetic species (S1, PS2, PS3, PS4) confined to particular endemic regions.
  • Autochthonous disease from southern Mexico to northern Argentina.
    • Countries where there have been no reports of paracoccidioidomycosis (PM) include:
      • Central America: Belize and Nicaragua
      • South America: Chile, French Guiana, Guiana, and Suriname
  • Paracoccidioides lutzzi causes a similar disease in humans, cases of PM due to P. lutzzi have only been reported in Brazil and Ecuador.

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Last updated: May 30, 2016