Pseudomonas aeruginosa is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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MICROBIOLOGY

  • Gram-negative non-fermenting, motile bacillus; known for blue-green pus (due to pyocyanin and pyoverdin pigments).
  • Non-fastidious organism, it can inhabit a variety of environments including soil and water (hot tubs, sinks, water faucets, respirators, disinfectants and contact lens cleaning solutions). Produces biofilm, toxins and proteases.
  • Drug resistance mechanisms: multiple pathways include active efflux pumps, chromosomal and inducible beta-lactamases, acquired genes and plasmid-mediated ESBLs (TEM, SHV, CTX-M), and altered permeability. Loss of protein porin OprD results in resistance to carbapenems, specifically imipenem. [4]

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Last updated: April 10, 2016