Johns Hopkins Antibiotic (ABX) GuideDiagnosisNeurologic

Prion Diseases

Trevor A. Crowell, M.D.
Prion Diseases is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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PATHOGENS

  • Prions are abnormally folded versions of cell membrane proteins which are otherwise normally found throughout the human body.
    • Abnormal versions are resistant to most types of proteolytic degradation including resistance to many chemical and physical methods of inactivation.
    • Can induce conversion of nearby proteins from the normal PrPC form to the abnormal and infective PrPSc form.
  • Prions cause transmissible spongiform encephalopathies (TSEs).

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Last updated: December 2, 2015