Intravenous immune globulin is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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INDICATIONS

FDA

  • Bone marrow transplant (to prevent graft vs host disease)
  • Primary immunoglobulin deficiency
  • Idiopathic thrombocytopenia (ITP)
  • Prevention of bacterial infections in HIV-infected children who are not receiving prophylaxis (FDA approved but generally not recommended); Kawasaki disease.
  • VZV post-exposure prophylaxis (if Varicella-Zoster immune globulin is not available)

NON-FDA APPROVED USES

  • Anemia due to parvovirus B19 infection.
  • Non-FDA approved indications with established efficacy: Guillain-Barre syndrome; steroid resistant dermatomyositis; multifocal motor neuropathy.
  • Non-FDA approved indications that is still controversial: patients with Strep TSS treated with IVIG had a trend toward a lower mortality rate.
  • Severe C. difficile-associated colitis (based on case reports) .

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Last updated: February 2, 2011