Hidradenitis Suppurativa is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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PATHOGENS

  • Inflammatory disease around abnormal and dilated hair follicles with secondary involvement of apocrine glands and surrounding structures, often with superinfection.
  • Genetic predisposition possible; 40% have family history of hidradentitis supperativa.
  • Pathogenesis believed to start with occlusion and dilation of the pilosebaceous unit → rupture → extrusion of follicular contents into dermis → chemotactic inflammatory response → influx of neutrophils, lymphocytes, histiocytes → abscess formation (thus it is both an inflammatory disease related to immune dysregulation and an infectious disease).
    • Infection appears to be a result of inflammatory occlusion of ducts rather than the underlying process for hidradenitis supperativa.
  • Microbiology: culture may yield mixed aerobic/anaerobic bacteria with S. epidermidis and S. aureus most commonly isolated.
    • Up to 50% of patients are culture negative.

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Last updated: July 2, 2016