Gentamicin is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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INDICATIONS

FDA

  1. Serious infections caused by susceptible strains of organism. With the exception of uncomplicated UTI, aminoglycosides are generally used in combination.
  2. Bacterial septicemia, including neonatal sepsis
  3. Skin, bone and soft tissue infections (including burns)
  4. Meningitis (poor penetration)
  5. Urinary tract
  6. Respiratory tract (poor penetration)
  7. Gastrointestinal tract (including peritonitis)
  8. Inflammatory ocular conditions that are steroid-responsive (opthalmic ointment and suspension)

NON-FDA APPROVED USES

  1. Pneumonia, hospital-acquired (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a 3rd/4th generation cephalosporin)
  2. Intra-abdominal infection (in combination with an agent with gram-positive and anaerobe coverage)
  3. Enterococcal endocarditis (in combination with ampicillin)
  4. Pelvic Inflammatory Disease (PID) (in combination with clindamycin)
  5. Pseudomonad infections (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a 3rd/4th generation cephalosporin)
  6. Brucella Species

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Last updated: March 18, 2011