Fever and Neutropenia is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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DEFINITION

  • Febrile neutropenia:
    • Fever: single oral temp >38.3°C (101°F) or temp >38°C (100.4°F) sustained for 1h AND
    • Neutropenia: absolute neutrophil count (ANC) < 500 cells/mm3 OR ANC predicted to decrease to < 500 cells/mm3 in 48h.
  • Signs and symptoms typical of bacterial infection (i.e., induration, erythema, pustulation, CXR infiltrates, CSF pleocytosis) may be absent.

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Last updated: January 15, 2016