Enterobacter species is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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MICROBIOLOGY

  • Gram negative, aerobic, motile bacilli of the Enterobacteriaceae family.
  • Major human pathogenic spp: E. cloacae (most common), E. aerogenes, E. gergoviae and Pantoea agglomerans.
    • E. sakazakii now classified as Cronobacter.
  • Organism often with high levels of drug resistance due to expression of (1) chromosomal AmpC beta-lactamases that are constitutive and inducible, (2) plasmid-encoded extended-spectrum β-lactamases (ESBLs) and (3) carbapenemases.
  • β-lactams must be present for activation of inducible beta-lactamases, so initial susceptibility reports may not detect resistance that can arise during therapy.

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Last updated: September 27, 2013