Endocarditis is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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PATHOGENS

  • Frequency (based on 1779 cases 2000-03 [32]):
Native Valve Endocarditis Pathogens (see individual pathogens)

Pathogen

Frequency

S. aureus

32%

Viridans streptococci

18%

Enterococcus

11%

Coagulase-negative staphylococcus

11%

Streptococcus bovis

7%

Streptococcus (other)

5%

HACEK organisms [Haemophilus parainfluenzae, Haemophilus aphrophilus, Actinobacillus actinomycetemcomitans,
Cardiobacterium hominis, Eikenella corrodens, Kingella kingii]

2%

Gram-negative bacilli

2%

Fungi [Candida species, Aspergillus species (note: blood cultures rarely positive for aspergillus)]

2%

Culture negative [consider HACEK organisms, nutritionally deficient Streptococcus species (e.g., Abiotrophia), Coxiella burnetii (Q fever),
Chlamydia psittaci, Mycoplasma spp., Legionella pneumophila, Bartonella species, Brucella species, Tropheryma whipplei]

8%

  • Prosthetic valve:
    • "Early" (< 60 days post-op): S. epidermidis (25%), S. aureus (20%), rest is a miscellany: enterococcus, Streptococcus sp, gram-neg bacilli, Candida sp, Diphtheroids, etc.
  • Infection drug use:
    • S. aureus, >> strep sp and mescellaneous other microbes



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Last updated: November 6, 2015