Daptomycin is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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INDICATIONS

FDA

NON-FDA APPROVED USES

  • Endocarditis caused by Enterococcus spp. resistant to vancomcyin, penicillin and aminoglycosides [1]
  • VRE infections including BSI, intra-abdominal infections, urinary tract infections, SSTI
  • Alternative therapy:
    • Instead of vancomycin for left-sided native valve endocarditis caused by MSSA [1]
    • S. aureus and Enterococcus spp. prosthetic joint infections
    • S. aureus and Enterococcus spp. native vertebral osteomyelitis [7]
  • Note: daptomycin should not be used for treatment of pneumonia

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Last updated: November 29, 2015