Clostridium tetani (Tetanus) is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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MICROBIOLOGY

  • Gram-positive bacillus, obligate anaerobe.
  • Spore wide spread in soil and animal feces.
  • Rod-shaped appearance on gram stain often likened to drumsticks or tennis rackets.
  • Toxin, tetanospasmin, causes tetanus: unopposed muscle spasm, contraction due to interference of toxin with neurotransmitters (including GABA and glycine).

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Last updated: April 4, 2016