Chloramphenicol is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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INDICATIONS

FDA

  • Note: for use only in those serious infections for which less potentially dangerous drugs are ineffective or contraindicated.
  • Acute infections caused by Salmonella typhi
  • Serious infections caused by Salmonella species, H. influenzae, specially meningeal infections, Rickettsia, Lymphogranuloma-psittacosis Chlamydia group, various Gram-negative bacteria causing bacteremia and meningitis.
  • Part of a cystic fibrosis regimen when other agents are ineffective or contraindicated.
  • Ocular infections (ophthalmic drops and ointments)

NON-FDA APPROVED USES

  • Lung abscess
  • Gas gangrene (in PCN allergic pts)
  • Brain abscess
  • Paratyphoid fever
  • Q fever (Coxiella burnetii)
  • Rocky mountain spotted fever and other endemic (murine or scrub) typhus infections caused by Rickettsia species
  • Ehrlichiosis
  • Meningitis in PCN-allergic patients.

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Last updated: January 31, 2016