Acanthamoeba is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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  • Free-living amoeba known to infection humans: Acanthamoeba spp, Naegleria fowleri, Balamuthia mandrillaris and Sappinia pedata. [13]
  • Ubiquitous, isolated worldwide from soil, air, fresh & salt water.
  • 2 stage life cycle:
    1. Actively feeding & dividing trophozoite
    2. Dormant cyst (double-walled, wrinkled cyst) which is resistant to chlorine and antibiotics. Encystation occurs under stress. [8]
  • Described as “Trojan horses,” they can also harbor intracellular bacteria. [13]

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Last updated: August 19, 2015