Staphylococci, coagulase negative is a topic covered in the Johns Hopkins Antibiotic (ABX) Guide.

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MICROBIOLOGY

  • Coagulase-negative staphylococci (CoNS) are aerobic, gram positive coccus, occurring in clusters. Frequently found on skin and mucous membranes.
  • Catalase positive but coagulase negative (while S. aureus is coagulase positive).
    • Major pathogen is S. epidermidis, colonies typically small, white-beige (about 1-2 mm in diameter).
    • Over forty recognized species of CoNS, with other major entities including S. lugdunensis and S. haemolyticus.
  • Many strains with propensity to produce biofilm, allowing for adherence to medical devices.
  • Usually resistant of penicillin and methicillin (oxacillin).

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