- Klebsiella granulomatis (formerly known as Calymmatobacterium granulomatis) is a member of the family Enterobacteriaceae; reclassification is based upon nucleotide relatedness to other Klebsiella spp. especially to K. rhinoscleromatis, another tropical infection (nasal).
- Pleomorphic, intracellular (macrophages > neutrophils), Gram-negative bacillus surrounded by a well-defined bipolar staining capsule (seen with Wright, Giemsa or Leishman stain)
- Organism has safety-pin appearance with stain under microscopy.
- Organism difficult to demonstrate microbiologically because it does not grow on any standard microbiological laboratory media.
- Culture achieved in the research settings using peripheral blood mononuclear cells cultivated with fetal calf serum after exposure to vancomycin and metronidazole for decontamination.
- Culture also has been successful on cyclohexamide-treated Hep-2 cell monolayers in RPMI 1640 medium, supplemented with fetal calf serum, penicillin, and vancomycin.
Klebsiella granulomatis (Granuloma inguinale, Donovanosis) was found in Johns Hopkins ABX Guide.
If you are a registered user, please log in below.
If not, learn more about gaining full access.
- Johns Hopkins Guides include up-to-date, authoritative content to help you treat patients and raise the standard of care.
Try these free topics now!
Johns Hopkins ABX Guide
Johns Hopkins Diabetes Guide
Johns Hopkins HIV Guide