Comparative bactericidal activities of daptomycin, glycopeptides, linezolid and tigecycline against blood isolates of Gram-positive bacteria in Taiwan.

Authors

Huang YT, Liao CH, Teng LJ, et al.

Institution

Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei County, Taipei, Taiwan.

Source

Clin Microbiol Infect 2008 Feb; 14(2) :124-9.

Abstract

In-vitro MICs and minimum bactericidal concentrations (MBCs) of daptomycin, linezolid, tigecycline, vancomycin and teicoplanin against Gram-positive bacteria were determined using the broth microdilution method for ten blood isolates each of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), including two vancomycin-intermediate S. aureus (VISA), vancomycin-resistant Enterococcus faecium and Enterococcus faecalis. One strain of VISA was tested in a time-kill synergism assay of daptomycin combined with oxacillin, imipenem, rifampicin and isepamicin. Daptomycin showed excellent in-vitro bactericidal activity against all the isolates tested, with no tolerance or synergism effects when combined with other agents, except with rifampicin against VISA. Vancomycin had better bactericidal activity against MRSA and MSSA than did teicoplanin. Linezolid had the poorest bactericidal activity against the isolates tested, with 100% tolerance by the MSSA and VRE isolates, and 80% tolerance by the MRSA isolates. Tolerance towards tigecycline was exhibited by 40% of the MRSA isolates, 100% of the MSSA and vancomycin-resistant E. faecalis isolates, and 90% of the vancomycin-resistant E. faecium isolates.

Mesh

Acetamides
Anti-Infective Agents
Daptomycin
Drug Resistance, Bacterial
Drug Therapy, Combination
Glycopeptides
Gram-Positive Bacterial Infections
Gram-Positive Cocci
Humans
Microbial Sensitivity Tests
Minocycline
Oxazolidinones
Staphylococcus aureus
Streptococcaceae
Taiwan
Teicoplanin
Time Factors
Vancomycin

Language

eng

Pub Type(s)

Journal Article

PubMed ID

18076671

Content Manager

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